The human neuromuscular system is a very complex structure, the branched sections of which perform different functions. Damage to one area of the central nervous system has a negative effect on the whole organism. Diseases of the neuromuscular system have an extensive list of syndromes and pathologies. One of the effective drugs that help to cope with many diseases is Prozerin.
What is Proserin
Tablets are a group of cholinomimetic drugs with anticholinesterase action. The drug Proserinum is used to treat the nervous system and pathologies characterized by a low tonus of smooth muscles. The medicine Prozerin helps increase the activity of the bronchial section, has a beneficial effect on the motility of the gastrointestinal tract, improves the condition of the bladder, is used as an emetic, and is sometimes used to improve labor. The drug slows the heartbeat, helps reduce intraocular and blood pressure.
Composition and form of release
Proserinum is available in the form of creamy pink granules, which are intended for the preparation of a suspension and solution for injection in 60 and 150 ml bottles. In pharmacies, white tablets with a rounded plane-cylindrical surface for oral administration are also sold. One pack contains 20 pieces. The active component of the drug is neostigmine methyl sulfate.
0.5 mg / 1 ml
15 mcg / 1 tablet
sucrose, potato starch, calcium stearate
Pharmacological group Proserine
Proserinum is a synthetic anticholinesterase that reversibly blocks cholinesterase. Due to this action, acetylcholine accumulates in organs and tissues, enhancing its action. As a result, neuromuscular conduction is restored in the body. Under the influence of the drug, the secretion of salivary, bronchial, sweat glands increases. This contributes to hypersalivation, bronchoremia, an increase in the acidity level of gastric juice.
If the drug is administered in large doses, then as a result of persistent depolarization in the region of synapses and accumulation of acetylcholine, it itself causes a violation of neuromuscular conduction. The effect of the drug coincides with the effects of excitation of cholinergic nerves. The metabolism of the active substance occurs in the liver, forming inactive metabolites. It binds to proteins by 15-25%. It is excreted from the body by the kidneys throughout the day.
Mechanism of action-
The medication has the ability to enhance smooth muscle tone, which helps to improve peristalsis, relax the sphincter and bladder. Proserine causes bronchospasm, tones skeletal muscles, normalizes uterine function. The drug is an antagonist of curariform antidepolarizing drugs, gives a direct cholinomimetic effect. When administered in certain doses, it can significantly enhance neuromuscular transmission.
Indications for use
The use of tablets and injections of the drug Proserinum is subcutaneously prescribed for such pathologies:
- motor impairment due to brain injury;
- myasthenia gravis;
- recovery from encephalitis, poliomyelitis, meningitis;
- open angle glaucoma;
- weak labor activity;
- atony of the bladder, digestive tract;
- neuritis of the facial or optic nerve;
- atrophy of the optic nerve, neuritis;
- decrease or absence of tone in the walls of the bladder, intestines, stomach
- neuromuscular transmission disorders;
Dosage and administration
Adults are allowed to use the drug in any form of release. Children are recommended to use the medicine in the form of granules, which are previously dissolved in 100 ml of water. The dosage is prescribed by the doctor individually, depending on age. In adult and pediatric ophthalmology, a solution is administered 1-2 drops in the conjunctival sac from 1 to 4 times / day.
Injections of the drug are prescribed in an individual dosage:
- with a myasthenic crisis, adults receive Prozerin injections from 0.25 to 0.5 g intravenously, and after improvement, subcutaneously with small interruptions;
- To stop the action of muscle relaxants, Atropine 0.5 mg is first administered intravenously, then after 2 minutes 1.5 mg Prozerin (intravenously);
- in the treatment of urinary retention, the drug is administered intramuscularly at 0.5 mg / day (5 injections in total).
The highest dose subcutaneously for adults: single 2 mg, daily 6 mg. Children's dosage after 1 year: subcutaneously 0.1 ml per 1 year of life, but not more than 0.75 ml of solution per 1 injection. As a rule, babies are prescribed injections 1 time / day, but sometimes the daily dosage is divided into 2-3 times. To stimulate labor, the drug is administered subcutaneously in 1 ml of a 0.05% solution 1-2 times at intervals after 1 hour.
The tablet form of the drug is taken orally, regardless of food intake, washed down with water. The average dose for an adult is 15 mg 2-3 times / day. The maximum daily dosage is 50 mg. The duration of treatment is prescribed by the doctor. On average, the course lasts 25-30 days. With insufficient therapeutic effect, after a month, treatment with Proserinum tablets can be prescribed again.
Use Proserinum with caution in Addison's disease. If large doses are prescribed intravenously, then an additional dose of Atropine is needed. During treatment, a cholinergic or myasthenic crisis may occur, after which a differential diagnosis is prescribed. With caution, medication should be used for intoxication of the body. After taking the medicine, you need to refrain from activities that require concentration.
The active substance neostigmine methyl sulfate after administration penetrates the placental barrier and is excreted in breast milk, albeit in small quantities. For this reason, the drug is used during pregnancy and lactation only for strict medical reasons. Proserinum is prescribed if the benefits of its use exceed the potential danger to the health of the mother and child.
The medicine can be prescribed for children of any age, but the dosage indicated by the doctor must be strictly observed. Babies under 10 years of age are prescribed 1 mg of the drug (suspension) per day. For adolescents over 10 years, the daily dosage is up to 10 mg. Prozerin injections are prescribed for children who have not reached 12 years of age 0.2-0.5 mg. The schedule of administration and duration of treatment is determined individually by the attending physician. You should know that Proserinum is prescribed to children in all dosage forms only in a hospital setting.
During the treatment of myasthenia gravis, Procerin tablets are prescribed along with glucocorticosteroids and anabolic hormones. Local anesthetics novocainamide, ganglion blockers weaken the cholinomimetic effects of the drug, which is manifested by narrowing of the pupil, increased motility of the gastrointestinal tract, bradycardia, accommodation spasm. Patients with myasthenia gravis Proserinum should be prescribed with caution simultaneously with anticholinergics, antibiotics with antidepolarizing effect and antiarrhythmic drugs.
Neostigmine methyl sulfate is an antagonist of non-depolarizing muscle relaxants that restores neuromuscular permeability. If, after anesthesia, respiratory depression and muscle weakness persist, the drug is used as an antidote. Like all cholinesterase inhibitors, Proserinum in combination with strychnine increases the vagus nerve tone, and with laxatives it enhances their effect.
Proserin and alcohol compatibility
During the course of therapy, taking ethanol-containing drinks is highly undesirable. With a combination of the drug with alcohol, orthostatic collapse is possible. Under the influence of ethanol, adrenomimetic effects are enhanced due to the release of adrenaline from the brain, which leads to a narrowing of blood vessels and a reduction in smooth muscles. The patient may experience severe anxiety, excessive sweating, tremor of the extremities, nausea, vomiting, facial flushing, itching.
With parenteral administration of Prozerin, a decrease in blood pressure may be observed. According to patients' reviews, with incorrect use of the drug, side effects occur in the form of:
- spastic reduction of peristalsis, vomiting, diarrhea, nausea, flatulence;
- tremor of the extremities, twitching of the muscles of the tongue, spasm of skeletal muscle, arthralgia, dysarthria, seizures;
- dizziness, weakness, headache, drowsiness, loss of consciousness;
- bronchospasm, shortness of breath, respiratory depression;
- frequent urination;
- miosis, visual impairment;
- tachycardia, arrhythmias, cardiac arrest.
According to the instructions, the drug can cause side effects due to an overdose. At the first undesirable signs, Proserinum treatment should be discontinued and a doctor should be consulted for symptomatic therapy. Overdose symptoms are associated with a cholinergic crisis: diarrhea, bradycardia, increased urination, decreased blood pressure, general weakness.
In addition to the period of pregnancy and lactation, the drug is contraindicated in case of hypersensitivity to its active components. Also, the drug Proserinum is not prescribed if a person has conditions such as:
- cardiac ischemia;
- severe atherosclerosis;
- bronchial asthma;
- ulcers of the duodenum or stomach;
- obstruction of the digestive tract or urinary tract;
- prostatic hyperplasia;
- acute form of infectious diseases.
Terms of sale and storage
The medicine Proserine in pharmacies is sold only by prescription, which is prescribed in Latin. Its independent use without medical prescription can lead to undesirable consequences for health. The medicine is stored, regardless of the form of release, in a dry, dark place in which there is no access to sunlight. Room temperature must not exceed 25 ° C. The shelf life of Proserinum in ampoules is 1.5 years, in tablets - 5 years. After this time, the medicine can not be used.
The direct analogue of Proserinum is Neostigmine Methyl Sulfate. Similar drugs by mechanism of action:
- Armin. It produces anticholinesterase, antiglaucoma action. It causes a strong miotic effect, lowers intraocular pressure.
- Ubretid. The medication helps increase the tone of the bladder, skeletal muscles, sphincter, ureters, enhances the function of the endocrine glands.
- Oxazil. A drug that produces a prolonged anticholinesterase effect. Increases the tone of the uterus, enhances the secretion of digestive, lacrimal, sweat, bronchial glands, promotes the expansion of blood vessels.
You can buy Proserinum in the pharmacy network or online store. The cost will vary depending on producer prices, volume, form of issue and marketing policy of the outlet. The average price of a drug in the Moscow region:
Price in rubles
ampoules 1 ml / 10 pieces
tablets 15 mg / 20 pieces
Alexandra, 23 years old Her husband was diagnosed with neuritis. Symptoms of the disease are similar to the clinical manifestations of a brain tumor, so when it was excluded, we were immensely pleased. Among others, Proserinum tablets were prescribed. The husband drank them in a course of 30 days, as prescribed by the doctor. There were no side effects. They got rid of neuritis with the help of complex therapy.
Alina, 27 years old. This drug was prescribed to me in combination with others for the treatment of osteochondrosis. After the first days of use, terrible side effects went on: wild abdominal pain, vomiting, diarrhea. I still remember with fear the effect of the pills. As it turned out, I have hypersensitivity to the active component of neostigmine methyl sulfate.
Vladimir, 35 years old I can not do without Proserinum. Atony of the bladder with all the ensuing consequences makes periodically drink a monthly course of tablets. The disease always recedes for a long period. As for the side effects, I can note that at 3-4 weeks of use I feel drowsiness and general weakness of the body.Attention! The information presented in the article is for guidance only. Materials of the article do not call for independent treatment. Only a qualified doctor can make a diagnosis and give recommendations for treatment based on the individual characteristics of a particular patient.